Pheochromocytoma (chromaffinoma) - a tumor originating from the chromaffin cells of the diffuse neuroendocrine... Read more »
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The main significance attached to increased production of tumor catecholamines. Pathological changes related to almost all organs and body systems, especially the cardiovascular, nervous and endocrine. Adrenaline has a stimulating effect primarily on the alpha2-and beta2-adrenergic receptors, norepinephrine - in the alpha1-and beta1,-adrenergic receptors. Effect of adrenaline causes an increase in heart rate, cardiac output, increase in systolic blood pressure and a... Read more »
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Pheochromocytoma differs from other hormonally active adrenal tumors most important and dangerous violations of hemodynamics. On the clinical course of isolated paroxysmal, persistent, and a mixed form of the disease. Paroxysmal form is the most frequent (35-85%) and characterized by a sudden sharp rise in blood pressure (up to 250-300 mm Hg. Art. And above), accompanied by headache, dizziness, palpitations, anxiety, pale skin, sweating, tremor throughout the body, ... Read more »
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The basis of laboratory diagnosis of disease is based on estimation of production and secretion of catecholamines. Determine daily excretion or the content of catecholamines in hourly urine sample. The accuracy of the method of study of excretion of catecholamines in the daily urine up to 96%. In addition, in the blood determine epinephrine, norepinephrine and dopamine in the urine - the content of adrenaline, noradrenaline and common to all catecholamine metabolite... Read more »
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Radical method of treatment of hormone-kateholamin producing tumors is surgical removal of tumors.
In the preoperative preparation of the main objective is to achieve stabilization of hemodynamic parameters. To stabilize the blood pressure using a-blockers (thropaphen, phentolamine, etc.). One of the most common medications is fenoksibenzamin (dibenzilin). Scheme is its use may be different. The initial dose is t... Read more »
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