Paget's disease (syn.: Paget's cancer of the breast nipple, breast cancer is similar to eczema) - a type of ca... Read more »
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Scientists do not know the exact cause of Paget's disease, but two main theories suggest how the disease develops. One theory suggests that cancer cells, called Paget cells, form tumors in the breast, and then moved from the breast to the nipple surface, as a result of developing Paget's disease - cancer of the breast nipple. This theory suggests that more than 97% of patients with Paget's disease have breast cancer or a... Read more »
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Process develops in the dissemination of primary cancer of the breast ducts in the epidermis. Primary cancer may be invasive or in situ. In the epithelium of ducts and the epidermis of the nipple, areola and surrounding skin areas reveal large neoplastic epithelial cells with hyperchromic nucleus and pale stained cytoplasm (Paget's cells), originating from the epithelium of apocrine glands. It is also possible the development of extra-mammary Paget's disease, most a... Read more »
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Symptoms of early Paget's disease include redness and scales on the skin of the nipple. Early symptoms can cause only mild irritation and usually does not become an occasion to refer to a doctor. Improvement in the skin may appear spontaneously, but it can not be regarded as a sign that the disease had disappeared. Further disease may be accompanied by more severe symptoms. At this stage, symptoms may include tingling, itching, high sensitivity, burning and pain. Ma... Read more »
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If the doctor suspects Paget's disease, it can be done a skin biopsy. Biopsy, the doctor removes a small tissue sample. A pathologist examines the tissue under a microscope to detect whether there are cells of Paget. The pathologist can use a technique called immuno histochemistry (to identify specific cells) to differentiate Paget's cells from other cells. A sample of discharge from the nipple may also be examined under the microscope for the presence of Paget cell... Read more »
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The most common treatment for Paget's disease - surgery. Specificity of treatment often depends on the stage of breast cancer.
Removal of the breast may be recommended when a diagnosis of cancer or running carcinoma. During this procedure, the surgeon removes the breast, the shell under the pectoral muscles, and some lymph nodes in the armpit. In some cases, when breast cancer is not malignant, the surgeon can sim... Read more »
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