|Tumor development has some connection with the rapid growth of the bone. Children with osteosarcoma are usually taller than the age norm, and the disease affects the most rapidly growing parts of the skeleton.
The development of bone tumors is often associated with trauma, but rather draws attention to trauma physician and forces to carry out X-ray examination
The sole agent of the environment, known as a stimulator of bone sarcomas - ionizing radiatio... Read more »
|Important role in the pathogenesis of osteogenic sarcoma is a tumor-suppressor mutation in the gene P-53. In some cases, tumor growth is influenced also inactivation of other tumor-suppressor genes - RBL (retinoblastoma-suppressive gene, which confirms a connection between these diseases), DCC gene, isolated from the cells of column-carcinoma (suggest that this gene is localized in the long arm of chromosome 18, which is often lacking in human osteosarcoma cells).... Read more »
|Main clinical symptom of osteosarcoma is pain over the affected area. Dull pain, constant with a gradual increase in intensity. Characteristic symptom is nocturnal pain. In 3 / 4 of patients may present with soft tissue component. Finiteness increased in volume, often looks swollen. Pain and increase lead to dysfunction. Duration of history is an average of 3 months.
Characteristic lesion metaphyses of long bones. The most frequent localization (about 50% of ... Read more »
|Diagnosis of osteogenic sarcoma based on histopathological criteria in conjunction with the radiographic data. Standard histological variants of osteosarcoma - osteoblastic (50%), hondroblasticheskaya (25%) and fibroblastic - less than 20%
1. Full X-ray examination.
This study allows to suspect the presence of osteosarcoma in a patient, but also reveals the presence of soft tissue component, pathological fractu... Read more »
|Treatment of osteogenic sarcoma includes the following steps:
1. Preoperative chemotherapy for the suppression of micrometastases in the lungs, reducing the size of the primary tumor and the tumor histological evaluation of tumor response to chemotherapy, which further defines the method of treatment. For the treatment of osteogenic sarcoma in the now, the following products: high-methotrexate, adriblastin, ifosfa... Read more »