Neuroblastoma - a malignant tumor, which was first described by Virchow in 1865 and called it a "glioma".
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The reasons for the development of neuroblastoma is not established. About 80% of the patients neuroblastoma is a spontaneous (sporadic) character; 20% - it can be attributed to hereditary forms of cancer pathology (familial predisposition to autosomal dominant). For the latter option is characteristic of an earlier age of the cases, the multiple primary tumors.
Many researchers believe that neuroblastoma occurs when normal fetal neuroblasts do not mature int... Read more »
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Neoplasms develop from sympathetic ganglia. There are three types of tumors, differing degrees of differentiation.
Ganglion neuroma composed of mature ganglion cells and is inherently benign tumors. She often calcify. It is believed that all the ganglion neuroma - a mature neuroblastoma. The literature describes cases of spontaneous or therapeutic maturation of neuroblastoma to ganglionevromy.
Ganglion neuroblastoma - an intermediate form of neoplasm... Read more »
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Initial symptoms of neuroblastoma have no specificity and can mimic a variety of pediatric diseases. This is due, firstly, the possibility of destruction of tumors and metastases of several areas of the body of the child, as well as metabolic disturbances caused by the growth of these tumor foci.
The clinical picture depends on the location of tumor, localization of metastases, the amount produced by tumor tissue of vaso active substances.
Growing in... Read more »
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Important test in the diagnosis and differential diagnosis of neuroblastoma is the determination of daily urinary excretion of catecholamines, their precursors and metabolites (vanilla almond and homo vanillic acid). In children with neuroblastoma, in contrast to other tumors, there has been a sharp increase in excretion of these substances in nearly 85% of cases. In addition, blood or urine of a patient are determined and other tumor markers: neuron-specific enolas... Read more »
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Despite the fact that neuroblastoma has been studied intensively by clinicians and experimentalists for over 100 years, the treatment of this disease remains an important issue of Pediatric Oncology. The choice of treatment strategy, at least, depends on two factors:
- Prognostic signs identified in children at the time of diagnosis of the disease;
- Tumor response to treatment.
Answering these questions chemotherapist, surgeon and radiologist can de... Read more »
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