Stage Hodgkin's disease
Before starting treatment, the physician should determine what the incidence of lymphoma, that is, the stage of disease. Superficial study can detect only a single enlarged lymph node, but some special methods can detect a much greater prevalence of the disease. The disease is divided into four stages depending on the prevalence and symptoms.
Treatment options and prognosis depend... Read more »
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Traditionally distinguish Hodgkin's disease and non-Hodgkin's lymphoma. Malignant lymphoproliferative diseases include tumors of B-cell, T cell and monocyte-histiocytic origin. The term malignant lymphoma suggested that T. Billroth. The first malignant lymphoma of the skin described by Jean aliber as mycosis fungoides, because the rash looked like mushroom caps.
The etiology and pathogenesis. At the core of malignant lymphomas of the skin is the neoplastic pr... Read more »
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Hodgkin's disease (lymphoma, malignant granuloma), a disease of lymphoid tissue.
Most researchers attribute it to the malignant tumors (lymphoma), but some believe that it is caused by some unknown virus, these two viewpoints are not contradictory. Lymphoid tissue is composed mainly of lymphocytes and reticular cells, which are predominantly in the lymph nodes and spleen, but also occur in the form of small nodul... Read more »
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The disease belongs to a large and rather heterogeneous group of diseases related to malignant lymphoma. The main cause of the disease is not entirely clear, but some epidemiological data, such as: the coincidence in time and place, multiple sporadic cases in non-blood relatives, they talk about the nature of infectious diseases, specifically viral (Epstein - Barr virus (born Epstein-Barrvirus , EBV)). Gene of the virus found in special studies in 20-60% of the biop... Read more »
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The discovery of giant cells Reid - Berezovsky - Sternberg and mononuclear precursor cells of Hodgkin's biopsy is a mandatory criterion for the diagnosis of Hodgkin's disease. According to many authors, but these cells are neoplastic. All other cells and fibrosis is a reflection of the immune response to tumor growth.
The main cells lymphogranulomatous tissue will usually be small, mature T-lymphocytes phenotype CD2, CD3, CD4> CD8, CD5 with different amou... Read more »
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Since the pathologic process may be involved any portion of widely represented in the lymphoid tissue of the body, clinical signs of Hodgkin's disease depen... Read more »
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The main criterion for diagnosis is the detection of giant cell Reid - Berezovsky - Sternberg and / or cell lymphoma in the biopsy, extracted from the lymph nodes. Used, and modern medical practices: (ultrasound of the abdominal cavity, computed X-ray or magnetic resonance imaging of the chest). In identifying the changes in the lymph nodes is required histological verification of diagnosis.
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Hodgkin's disease - a malignant disease, which can occur very rapidly (from 4 to 6 months), but sometimes it lasts much longer - up to 20 years. Without treatment, less than 10% of patients survive for 10 years from the onset. However, modern treatments can provide long-term, sometimes complete remission. According to the National Cancer Institute (USA), those with complete remission lasting more than 5 years after treat... Read more »
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