|Microscopically distinguish two types of hepatoblastoma:
1. epithelium, consisting only of epithelial cells;
2. mixed, epithelial-mesenchymal type.
In the epithelial type of exhibit two types of cells: the first type - fetal, very small (compared to normal) hepatocytes with a relatively large core and a different number of mitoses.
Trabeculae are wrong, dense rows of two young (as in the fetal liver) cells in each. There are also vacuolated cells... Read more »
|Specific symptoms exist. On palpation the abdomen is usually detectable tumor mass in the right upper quadrant, or tumor is detected in connection with the increasing size of the stomach. Common signs include anorexia, weight loss, malaise, febrile state.
Laboratory data: anemia, leukocytosis with polinukleozom and left shift, elevated ESR, hyper thrombocytosis due to intratumoral formation of platelets, elevated transaminases, lactate dehydrogenase, alkaline... Read more »
|Usually by the time of diagnosis, determine the size of the tumor are large, but still no metastases. Early diagnosis of cancer is always difficult because of prolonged asymptomatic.
Scintigraphy and ultrasound can determine the topography of the disease. Liver biopsy is associated with risk of hemorrhage. Recommend an early exploratory laparotomy and, if possible, resection. Gipertrombotsitoz is an indication of malignancy. The presence of alpha-fetoprotein ... Read more »
|Surgical treatment: resection of the liver together with the tumor, chemotherapy or a transplant.
What happens after treatment?
After all the treatment program, patients should be under constant medical supervision and undergo examination (chest X-ray, ultrasound, CT, MRI).
An important method of investigation is to determine the level of AFP, on the basis of which to judge the effectiveness of treatment... Read more »