Ewing's sarcoma (Latin endothelial myeloma) - malignant tumor of the bone skeleton. Ewing's sarcoma usually affects the lower part of the long bones, ribs, ... Read more »
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For bone sarcomas is characterized by rapid growth and early metastasis. Ewing's sarcoma is the second in frequency among malignant bone tumors in children - is 10-15%. This tumor is rare in children younger than 5 years and adults older than 30 years. The peak incidence occurs in 10-15 years.
The cause of malignant bone tumors is not yet known, however, proved that in 40% of the occurrence of bone sarcoma provokes injury.
There is some connection betw... Read more »
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Histological study of Ewing's sarcoma family of tumors, and all PNET are represented as unstructured aggregates of small tumor cells separated by fibrous layers. Cells have the correct form, contain round or oval nucleus. Encased in the cell nuclei dispersion of chromatin has a characteristic "mirror" look. In some nuclei, mitotic figures are visible.
Pathomorphological features of Ewing's sarcoma and PNET, revealed by histological examination, are insufficie... Read more »
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• Pain
The first symptom is pain, which, in contrast to the inflammatory process is not going down alone (increased at night, no relief at a fixed extremities).
As the tumor begins to suffer a function nearby joint, and then developed palpable tumors, often with a pathological fracture (late sign).
On the third - the fourth month of the onset of the pain at first disturbed, and then stops the movement in the near joint.
• Raising the temperature ... Read more »
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Biopsy of the tumor. Enough material can sometimes be obtained from the soft tissue component. If this is impossible, the material obtained from the site of bone bordering the medullary canal.
• X-ray chamber.
• X-rays and CT scans of the lungs.
• Aspiration biopsy or bone marrow from multiple locations (as Ewing's sarcoma has a tendency to metastasize to bone marrow).
• Bone scan can detect other lesions in the bones, as you may have multiple bone metas... Read more »
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Multicomponent chemotherapy (using drugs - vincristine, adriamycin, ifosfamide, cyclophosphamide, actinomycin, vepezid in combination). In modern treatment programs used preoperative and postoperative chemotherapy, taking into consideration also the histological tumor response to treatment. Good tumor response to chemotherapy is the presence of at least 5% of live tumor cells.
• Radiation therapy to the lesion in high doses. With the development of lung metastase... Read more »
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